Pronunciation: [ˈɪɡf a͡ɪ ˌɛsˈɛm sˈiː] (IPA) 
The spelling of the word "IGF I SmC" can be confusing. IGF I stands for insulin-like growth factor I, while SmC refers to somatomedin C, another hormone involved in growth. The correct pronunciation of IGF I is /ˈɪnsjʊlɪn laɪk ɡrəʊθ ˈfæktər ˈaɪ/. SmC is pronounced /ˌsoʊmətoʊˈmi:dɪn si:/. Together they form the complex term IGF I SmC, pronounced as /ˈɪnsjʊlɪn laɪk ɡrəʊθ ˈfæktər ˈaɪ/ /ˌsoʊmətoʊˈmi:dɪn si:/
IGF I SmC, also known as Insulin-like Growth Factor-I Splice Variant C, is a specific isoform of the Insulin-like Growth Factor-I (IGF-I), a hormone that plays a crucial role in growth and development of an organism.
IGF-I SmC is derived from alternative splicing of the IGF-I gene, resulting in a variant with a unique sequence of amino acids. This isoform is primarily expressed in skeletal muscles, hence the abbreviation "SmC" which stands for skeletal muscle C. It is produced and secreted by both muscle cells and liver cells, and its expression is regulated by various growth factors and hormones.
IGF-I SmC acts as a potent anabolic agent, promoting muscle growth and inhibiting protein breakdown. It enhances the synthesis of proteins within muscle cells, leading to increased muscle mass, improved muscle strength, and overall muscle function. Additionally, IGF-I SmC stimulates the proliferation and differentiation of muscle stem cells, thereby contributing to muscle repair and regeneration.
In addition to its effects on muscles, IGF-I SmC also plays a role in other physiological processes such as regulation of metabolism, tissue growth, and bone development. It exerts its actions by binding to specific receptors, activating intracellular signaling pathways, and regulating gene expression.
Overall, IGF-I SmC is a specialized isoform of Insulin-like Growth Factor-I that specifically targets skeletal muscles, aiding in their growth, repair, and maintenance.
