DRUG METABOLIC DETOXICATIONS Meaning and
Definition
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Drug metabolic detoxifications refer to the series of enzymatic processes carried out by the body to eliminate or neutralize drugs and other foreign substances. When drugs are introduced into the body, they undergo various chemical transformations, known as drug metabolism, which allow for their elimination. This detoxification process is primarily accomplished in the liver, although other organs such as the kidneys and lungs also contribute.
Drug metabolic detoxifications involve two major phases: Phase I and Phase II reactions. Phase I reactions involve the modification of the drug molecule through oxidation, reduction, or hydrolysis, resulting in the formation of intermediate metabolites. These reactions are predominantly catalyzed by a group of enzymes called cytochrome P450 enzymes. Phase II reactions, also known as conjugation reactions, involve the attachment of a polar molecule to the intermediate metabolite from Phase I. This makes the drug more water-soluble and easily excretable by the body.
The purpose of drug metabolic detoxifications is to convert drugs into more polar and less toxic compounds to facilitate their elimination from the body. By altering the chemical structure of drugs, the detoxification process helps to make them more easily recognized and removed by the body's excretory systems, such as through urine or feces. This process is essential for maintaining homeostasis and preventing the toxic buildup of drugs or other foreign substances in the body.
Common Misspellings for DRUG METABOLIC DETOXICATIONS
- srug metabolic detoxications
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Similar spelling word for DRUG METABOLIC DETOXICATIONS
- Metabolic Drug Detoxications.
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