ABL GENE Meaning and
Definition
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The abl gene is a specific gene often referred to as Abelson proto-oncogene. It is a gene that codes for a protein called ABL tyrosine kinase, which plays a crucial role in regulating cell growth and division. This gene is found in humans and other vertebrates.
The ABL protein is involved in signal transduction pathways, which are responsible for transmitting signals from the exterior of the cell to the nucleus, and therefore, influencing cellular processes such as proliferation, differentiation, and apoptosis. This protein is typically found in two forms, a cytoplasmic form and a nuclear form, both of which are important for its various functions.
The abl gene has been extensively studied in the context of cancer development and progression. In some cases, mutations or alterations in the abl gene can lead to the formation of a fusion gene known as BCR-ABL. This fusion gene is commonly associated with certain types of leukemia, such as chronic myeloid leukemia (CML). The BCR-ABL fusion protein produced from this gene fusion contributes to uncontrolled cell growth and division, leading to the development of cancer.
Understanding the abl gene and its associated proteins can provide valuable insights into how normal cellular processes are regulated and dysregulated in diseases such as cancer. Researchers continue to investigate the potential of targeting the ABL protein and related signaling pathways for the development of novel cancer therapies.
Common Misspellings for ABL GENE
- zbl gene
- sbl gene
- wbl gene
- qbl gene
- avl gene
- anl gene
- ahl gene
- agl gene
- abk gene
- abp gene
- abo gene
- abl fene
- abl vene
- abl bene
- abl hene
- abl yene
- abl tene
- abl gwne
- abl gsne
- abl gdne
Etymology of ABL GENE
The word abl is an abbreviation of Abelson. The Abelson gene is named after a renowned scientist, J. Michael Bishop, who, along with his colleague Harold Varmus, discovered this gene and its association with certain types of leukemia. Bishop named the gene after his mentor, Dr. Elias James Abelson, as a tribute to his contributions to cancer research. Hence, the word abl gene originated from the name Abelson.
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